American Society of Microbiology ABMM - ABMM 模擬練習
A patient develops a febrile illness with a diffuse petechial rash after a camping trip. Serological testing reveals a four-fold rise in antibody titer to Rickettsia rickettsii. The vector responsible for transmitting this organism is a:
正解: D
Caspofungin, micafungin, and anidulafungin belong to the echinocandin class of antifungal agents. Their primary mechanism of action involves the non-competitive inhibition of:
正解: A
A patient with a history of travel to a rural area develops a febrile illness with myalgias and thrombocytopenia. Laboratory testing reveals the presence of morulae within circulating leukocytes. The MOST likely diagnosis is:
正解: D
An immunocompromised patient develops a disseminated fungal infection. Blood cultures are consistently negative. However, a serum beta-D-glucan assay is markedly elevated. Tissue biopsy reveals the presence of hyaline, septate hyphae with dichotomous branching. The MOST likely causative organism is:
正解: D
A research team is investigating the mechanism of bacterial resistance to a novel fluoroquinolone antibiotic.
They isolate a resistant strain of Escherichia coli from a patient with a urinary tract infection. Genetic analysis of this strain reveals a point mutation in the gyrA gene. This mutation MOST likely results in:
They isolate a resistant strain of Escherichia coli from a patient with a urinary tract infection. Genetic analysis of this strain reveals a point mutation in the gyrA gene. This mutation MOST likely results in:
正解: C
A microbiology laboratory receives a CSF sample from a patient with suspected fungal meningitis. India ink staining reveals encapsulated yeast cells. Culture on Sabouraud dextrose agar grows creamy white colonies.
The MOST likely organism is:
The MOST likely organism is:
正解: D
A Gram-positive rod is isolated from the blood culture of a neonate with sepsis. The organism exhibits weak beta-hemolysis on sheep blood agar, is catalase-positive, hydrolyzes esculin in the presence of bile, and demonstrates characteristic "tumbling" motility in a wet mount prepared from a broth culture incubated at 25°C. Which organism is most likely?
正解: A
A clinical microbiology laboratory is implementing a new quality control procedure for blood culture media.
To ensure the media supports the growth of a wide range of clinically significant organisms, they should include:
To ensure the media supports the growth of a wide range of clinically significant organisms, they should include:
正解: C
A patient with a history of recurrent sinopulmonary infections and bronchiectasis is diagnosed with primary ciliary dyskinesia. Sputum cultures are most likely to persistently grow which of the following organisms?
正解: D
A laboratory worker sustains a needlestick injury while handling a blood sample known to be positive for Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg). The worker has completed the HBV vaccination series and has a documented anti-HBs titer >10 mIU/mL one month ago. What is the recommended post-exposure prophylaxis?
正解: C
A microbiology laboratory is asked to identify the causative agent of a fungal keratitis. Microscopic examination of corneal scrapings reveals broad, aseptate hyphae with right-angle branching. The MOST likely genus is:
正解: B
A clinical microbiology laboratory is performing Gram staining on a sputum sample. After adding the crystal violet stain, a delay in the washing step with decolorizer (alcohol-acetone) would MOST likely result in:
正解: C
A patient develops a febrile illness with a diffuse petechial rash after a camping trip. Serological testing reveals a four-fold rise in antibody titer to Rickettsia rickettsii. The vector responsible for transmitting this organism is a:
正解: D
A child presents with a characteristic "slapped cheek" rash followed by a lacy, reticular rash on the trunk and extremities. The causative agent is a single-stranded DNA virus belonging to the family Parvoviridae, known as:
正解: B
During the processing of stool specimens for ova and parasite examination, the formalin-ethyl acetate concentration procedure primarily serves to:
正解: D